甲状腺乳头状癌CD44v6表达的免疫组化研究

AN IMMUNOHISTOCHEMICAL STUDY OF EXPRESSION OF CD44v6 IN THYROID PAPILLARY CARCINOMA

目的 :探讨甲状腺乳头状癌 CD44v6的表达与淋巴结转移的关系。方法 :应用免疫组化 SP法对 2 0例有颈淋巴结转移的甲状腺乳头状癌 ( PTC+LNM) ,3 0例无颈部淋巴结转移的甲状腺乳头状癌 ( PTC) ,10例甲状腺腺瘤 ( TA)和 10例正常甲状腺组织( NTT)进行了 CD44v6检测。结果 :PTC+L NM组的 CD44v6阳性率显著高于 PTC组 ,TA组和 NTT组者 ( P<0 .0 5 )。结论 :( 1)CD44v6的阳性表达与甲状腺乳头状癌的颈淋巴结转移密切相关 ,CD44v6有助于甲状腺乳头状癌的颈淋巴结转移。 ( 2 )

Objective :To study the relation between the Cervical lymphonode metastasis (LNM) and expression of CD44v6 in papillary thyroid carcinoma(PTC). Methods :20 cases of PTC with LNM ,30 cases of papillary thyroid carcinoma without LNM,10 cases of thyroid adenoma(TA) and 10 cases of normal thyroids tissue(NTT) were studied by SP immunohistochemical method .Results:The positive rates of expression of CD44v6 in group PTC LNM was higher than that in group PTC, TA and NTT(P<0.05).Conclusion :Overexpression of CD44v6 indicates the PTC's biological feature of easy LNM and can act as a relatively good tumor metastatic marker of PTC.[