神香苏合丸对狗冠状动脉两步结扎法急性心肌梗塞的影响

Effect of Shenxiang Suhe pill on acute myocardial infarction in dogs

目的 :观察神香苏合丸对狗急性心肌梗塞的影响。方法 :2 7只狗 ,分 4组 ,其中神香苏合丸分小剂量组和大剂量组 ,予以灌胃给药。狗麻醉后行气管插管 ,开胸分离冠状动脉前降支并行两步法结扎 ,4h后取心肌行NBT染色 ,确定心肌梗塞程度 ,并做阴性对照组和阳性对照组试验。结果 :狗冠状动脉前降支结扎后死亡率为 4 4.4 % ,而给大剂量神香苏合丸组的心肌梗塞后死亡率有明显下降趋势 (与阴性对照组比 ,P <0 .0 5) ,并能降低ST T的抬高程度 ,缩小心肌梗塞范围 ,与等同剂量的麝香保心丸阳性对照组结果相似。小剂量神香苏合丸组未能降低心肌梗塞后的死亡率 ,虽有降低ST T的抬高程度和缩小心肌梗塞范围 ,但未能达到显著的水平。结论 :口服神香苏合丸可显著降低狗急性心肌梗塞及其诱导心电图ST T的抬高程度 。

OBJECTIVE:To investigate the effect of Shenxiang Suhe pill on acute myocardial infarction(AMI) in dogs.METHOD:Twenty seven dogs were devided at random in four groups,ie normal saline(NS) control,Shexiang Baoxin pill control,Shenxiang Suhe pill high dose group and low dose group.The drugs were administrated orally.AMI was performed with two step method of coronary artery ligation.RESULTS:Shenxiang Suhe pill high dose group,20 times that of recommended dose for human beings,decreased the levation of ST T after AMI and reduced infant size significantly(P<0.05).The protective effect of Shenxiang Suhe Pill was similar to that of Shexiang Baoxin pill.CONCLUSION:Shenxiang Suhe pill is effective in the treatment of AMI in dogs.