硝苯吡啶与格列本脲相互作用对正常大鼠和高血糖大鼠血糖水平的影响

The influence of nifedipine and glibenclamide to plasma glucose level in the fasted and adrenaline hydrochloride induced hyperglycemic rat

目的 :研究硝苯吡啶以及硝苯吡啶与格列本脲合用对空腹大鼠和肾上腺素诱发高血糖大鼠血糖水平的影响。方法 :本实验采用葡萄糖氧化酶法测定血糖含量。结果 :硝苯吡啶 2 .5mg/kgig使空腹大鼠血糖水平显著升高(P <0 .0 1 ) ,并加重肾上腺素诱发的高血糖反应。而硝苯吡啶与降糖药格列本脲 0 .9mg/kg合用时不影响空腹大鼠的血糖水平 ,硝苯吡啶对肾上腺素诱发高血糖大鼠灌胃格列本脲后的降血糖作用亦无明显影响。结论 :尽管硝苯吡啶对空腹大鼠以及肾上腺素诱发高血糖大鼠有显著升高血糖的作用 。

OBJECTIVE:To study the effects of nifedipine and the interaction of nifedipine and glibenclamide on the plasma glucose levels in the fasted and adrenaline hydrochloride induced hyperglycemic rat.METHODS:Plasma glucose was measured with glucose oxidase method.RESULTS:Nifedipine(2.5mg/kg i.g.) significantly increased plasma glucose level in the fasted rat,and further aggravated the hyperglycemia induced by adrenaline hydrochloride(P<0.01).Plasma glucose did not altered after administration of nifedipine and glibenclamide 0.9mg/kg simultaneously in the fasted rat,and nifedipine neither affected the hypoglycemic action of glibenclamide in the adrenaline hydrochloride induced rat.CONCLUSION:Although nifedipine significantly increased plasma glucose level in the fasted and adrenaline hydrochloride induced rat,it had no adverse influence on the hypoglycemic action of glibenclamide.