N-甲基-N-乙基-N,N-二(2-硬脂酰氧)乙基溴化铵的合成及应用

Synthesis and Application of N-Methyl-N-Ethy-N,N-Bis(2-Stearoyloxy)Ethyl Bromide

采用先季铵化再酯化的合成路线,合成了酯基季铵盐N-甲基-N-乙基-N,N-二(2-硬脂酰氧)乙基溴化铵。考察了物料摩尔比、反应温度和反应时间对中间体N-甲基-N-乙基-N,N-二羟乙基溴化铵的影响,所得中间体与硬脂酰氯酯化得到酯基季铵盐产品,产物活性物质含量质量分数达98%以上,采用IR、MS和1H-NMR对合成酯基季铵盐进行了结构表征。对合成的酯基季铵盐的柔软性能进行研究,结果表明与双十八烷基二甲基氯化铵(D1821)相近。

The N-methyl-N-ethy-N,N-bis（2-stearoyloxy）ethyl bromide was successfully synthesized by a novel route,which could be described as quaternization first,and then sterification.The effects of material molar ratio,reaction temperature and reaction time on the intermediate product N-methyl-N-ethyl-N,N-bis（2-hydroxyethyl） ammonium bromide were examined.The final product N-methyl-N-ethy-N,N-bis（2-stearoyloxy）ethyl bromide was successfully synthesized with high yield（The active substance content of product was more than 98%） by reacting with stearyl chloride.The structure of the quaternary products was characterized using IR,MS and 1H NMR.The study on softening showed that the performance of prepared esterqueats is better than that of the D1821 former is as better as the latter.