Dukes B,C期结肠癌术后两种方案化疗的临床对照研究

Clinical research of Dukes B,C period colon cancer treated with the two schemes of chemotherapy

目的探讨F0LFOX与FOLFOX4两种化疗方案治疗Dukes B,C期结肠癌术后的临床效果。方法回顾性分析我院收治的应用FOL-FOX与FOLFOX4方案化疗的Dukes B,C期结肠癌术后患者的临床资料。观察两种化疗方案的复发率、5年生存率及毒副反应发生情况。结果两组患者复发率及5年生存率无显著性差异,但FOLFOX4患者复发时间明显延后;两组患者毒副反应发生率比较无显著差异,但F0LFOX4组Ⅲ度以上毒副反应发生率明显低于F0LFOX组。结论 F0LFOX4化疗方案复发率较低,5年生存率较高,且毒副反应相对较轻,更易被患者接受,值得临床广泛应用于中期结肠癌的术后化疗。

OBJECTIVE To discuss the clinical effect of Dukes B,C period after colon cancer treated with F0LFOX and FOLFOX4.METHODS The clinical data of Dukes B,C period colon cancer patients were analyzed retrospectively who were treated with F0LFOX and FOLFOX4.Watched the relapse rate,5 years survival rate and toxic reaction conditions of the two chemotherapy patients.RESULTS The recurrence rate and 5-year survival rate of the two groups had no significant difference,but FOLFOX4 patients relapse time were delayed obviously;Two groups of patients,incidence of adverse reaction had no remarkable difference,but F0LFOX4 group Ⅲ degrees above adverse reaction rate was significantly lower than the F0LFOX group.CONCLUSION F0LFOX4 chemotherapy for the recurrence rate was low,5 years survival rate was high,and it had the relatively light toxicity,patients were more likely to be accepted,and was worth using widely.