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妊娠期糖尿病患者脂联素水平与胰岛素抵抗的关系 被引量：6

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摘要 目的分析脂联素(APN)与胰岛素抵抗(HOMA-IR)的关联性,探讨APN水平变化在妊娠期糖尿病中的发病机制,寻找早期诊断和防治妊娠期糖尿病的新途径。方法以孕中期糖筛查试验结果将病例分为3组:妊娠期糖尿病(GDM)组24例、妊娠期糖耐量受损(GIGT)组32例,正常糖耐量(GNGT)组30例作为对照组。分别记录3组病例在孕早中晚期的体重,空腹血糖、胰岛素,留置血清同批测定脂联素。根据空腹血糖和胰岛素水平计算胰岛素抵抗指数。结果 3组病例随着孕早中晚期孕程增加其APN水平各自均呈下降趋势,胰岛素抵抗指数(INR-IRI)呈上升趋势,同组相邻期间比较差异有统计学意义(P<0.05)。而在同一孕程,GDM组APN水平低于GIGT组、GNGT组,差异有显著性。GDM组APN水平与HOMA-IRI负相关。结论妊娠期糖尿病病人孕期,尤其是在孕早期即出现了APN水平显著下降,APN水平与HOMA-IRI呈负相关。APN对于妊娠期糖尿病的早期诊断、早期干预具有临床意义,早期补充外源性APN也是防治妊娠期糖尿病的一种探索。
作者 许青
机构地区 福建莆田学院附属医院妇产科
出处 《海峡药学》 2012年第4期160-161,共2页 Strait Pharmaceutical Journal
关键词 妊娠期糖尿病 脂联素 胰岛素抵抗 糖耐量试验
分类号 R969.4 [医药卫生—药理学]
  • 相关文献

参考文献8

  • 1曹泽毅主编.妊娠期糖尿病,中华妇产科学(J).北京:人民卫生出版社,1999,514.
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二级参考文献16

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  • 9Haluzik M,Parizkova J,Haluzik M M,et al.Adiponectin and Its Role in the Obesity-Induced InsulinResistance and Related Complications[J].Physiol Res,2004,53(2):123.
  • 10Vasseur F,Helbecque N,Dina C,et al.Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians[J].Human Molecular Genetics,2002,11(21):2607.

共引文献18

同被引文献112

引证文献6

二级引证文献29

海峡药学
2012年 第4期

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