益气养阴活血方对糖尿病肾病患者血清胱抑素C及尿微量白蛋白的影响

Clinical research of Yiqi Yangyin Huoxue therapy on cystatin C and microalbuminuria of diabetic nephropathy

目的观察益气养阴活血方对糖尿病肾病(DN)患者血清胱抑素C(Gys C)及尿微量白蛋白的影响。方法将60例DN患者随机分为2组。对照组30例予西医常规治疗,治疗组30例在对照组治疗基础上加益气养阴活血方治疗,2组均治疗3个月后观察疗效,比较治疗前后Cys C、尿微量白蛋白及血肌酐(Cr)变化。结果治疗组总有效率86.7%,对照组总有效率56.7%,2组比较差异有统计学意义(P<0.01),治疗组疗效优于对照组。治疗组治疗后Cys C、尿微量白蛋白均较本组治疗前、对照组治疗后降低(P<0.01,P<0.05),对照组治疗后Cys C较本组治疗前降低(P<0.01)。结论益气养阴活血方治疗DN有良好的临床效果,可降低Cys C,减少蛋白尿,改善肾功能及主要临床症状,减缓病情发展。

Objective To investigate the intervention role of Yiqi Yangyin Huoxue therapy on cystatin c and microalbuminuria of the diabetes nephritis(DN) patient.Methods 60 cases of DN were divided into the control group(n=30),which were treated by the conventional treatment,and the treatment group(n=30) which were treated by Yiqi Yangyin Huoxue therapy combined with the conventional treatment.The effect in two groups was observed after three months of treatment.The changes of cystatin C(Cys C),microalbuminuria and Cr in serum were detected.Results The total effective rate in the treatment group(86.7%) was superior to that in control group(56.7%,P<0.01).Cys C and microalbuminuria after treatment was decreased compared with that before treatment in treatment group(P<0.01).Cys C after treatment was decreased compared with that before treatment in control group(P<0.05).Cys C and microalbuminuria in treatment group was decreased compared with that in control group after treatment(P<0.01).Conclusion Yiqi Yangyin Huoxue therapy has a good effect on the treatment of diabetic nephropathy,improve renal function and main clinical symptoms and slow disease progression.