血清病毒载量与丙型肝炎相关肾病转归

RELATIONSHIP BETWEEN SERUM VIRAL LOAD AND PROGNOSIS OF HEPATITIS C RELATED KIDNEY DISEASE

目的探讨血清病毒载量与丙型肝炎相关肾病转归的关系。方法采用前瞻性研究方法,评价46名丙型肝炎(HC)相关肾病患者抗病毒治疗的效果。结果 46名HC相关肾病患者完成6个月抗病毒治疗后出现12例HCV-RNA阴转患者,检测这12例治疗前后血清丙氨酸转氨酶(ALT):从平均(92.4±62.2)IU/L降低至(54.1±34.3)IU/L,P=0.005;治疗前后24小时尿蛋白:从平均5.2 g降到1.40 g,P=0.001。结论血清病毒载量与丙型肝炎相关肾病转归存在相关性。通过抗病毒治疗,对改善肾脏病理有作用,是治疗HC相关肾病患者的有效手段。

Objective To investigate the relationship between serum virus load and hepatitis C（HC） related renal disease.Methods A prospective method was used to evaluate curative effects of antiviral therapy for 46 HC related renal disease patients.Results After 6 months of antiviral therapy For 46 patients,12 cases showed HCR-RNA negative conversion,and the level of serum alanine aminotransferase（ALT） decreased from 92.9±62.2 to 54.1±34.3IU/L（P0.05）;and 24-hour urine protein from 5.2g to 1.4g（P0.001）before and after treatment.Conclusion The serum virus load is associated with HC related renal disease.The renal pathological symptom can be improved by antiviral therapy and it is an effective method for treating HC related kidney disease.