连续性血液净化治疗对纠正重症急性胰腺炎患者氧化应激紊乱的观察

Continuous blood purification for the treatment of oxidative stress disorder in patients with severe acute pancreatitis

目的探讨连续性血液净化(CBP)治疗重症急性胰腺炎(SAP)的作用机制。方法对收治的52例SAP随机分为治疗组和对照组,每组26例,对照组用SAP常规疗法,治疗组在常规疗法的基础上用CBP治疗5天,于治疗前后检测血淀粉酶(AMS)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)水平。结果治疗组治疗后FBG、WBC、AMS、SOD、CAT、GSH-PX和MDA水平均有改善(P<0.01),对照组治疗后仅有AMS水平改善(P<0.01)。结论 CBP治疗SAP对患者的氧化应激功能紊乱有纠正作用。

Objective To explore the mechanism of action of continuous blood purification（CBP） in treatment of severe acute pancreatitis（SAP）.Methods 52 inpatients with SAP were randomly divided into a therapeutic group and a control group,26 cases included in each group.The control group received traditional therapy for SAP,the therapeutic group were given traditional therapy plus CBP for 5 days.Before and after treatment,the measurements of serum amylase（AMS）,superoxide dismutase（SOD）,catalase（CAT）,glutathione peroxidase（GSH-PX） and malondialdehyde（MDA） levels were done.Results After treatment,the therapeutic group in levels of FBG,WBC,AMS,SOD,CAT,GSH-PX and MDA were all improved（P0.01）,the control group in AMS level alone improved（P0.01）.Conclusion CBP is effective on regulating the oxidative stress disorder in patients with SAP.