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鼻息肉中Livin及Mcm3的表达及其意义 被引量:1

Expression and significance of Livin and Mcm3 in nasal polyps
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摘要 目的探讨凋亡抑制蛋白Livin和Mcm3即微小染色体维持蛋白3在鼻息肉中的表达水平及特点,以及与鼻息肉临床分型分期和术后复发率的相关性。方法采用免疫组化SP法及计算机图像分析系统,检测40例单纯鼻息肉患者及6例正常钩突黏膜中Livin及Mcm3的表达,并与鼻息肉临床分期及术后复发率进行关联性分析。结果 Livin在鼻息肉与正常黏膜对照组之间的表达差异具有统计学意义(P<0.05)。Mcm3在鼻息肉与正常黏膜对照组之间的表达差异无统计学意义(P>0.05)。Livin、Mcm3联合表达强度与鼻息肉临床分型分期之间呈正相关关系(R's=0.606,P<0.05);Livin、Mcm3联合表达强度与鼻息肉术后复发率之间呈直线正相关关系(R=0.958 8,t=4.7779,P<0.05)。结论 Livin过度表达所致细胞凋亡受抑制在鼻息肉腺体发生发展的过程中可能具有重要作用,而Mcm3标志的鼻息肉细胞增殖活性的提高在其发病机制中可能处于一个相对次要的地位。Livin及Mcm3联合检测可作为预测鼻息肉患者术后复发率的参考指标。 Objective To explore expressions of Livin and Mcm3 in nasal polyps(NP),and to investigate their relationships with NP′s clinical stages and recurrence rate.Methods Expressions of Livin and Mcm3 were detected in 40 cases of NP and 6 cases of normal mucosa of the uncinate process by immunohistochemistry and the image analytical system.Results Positive expression of Livin between NP and normal mucosa was statistically different(P〈0.05),while Mcm3 was not(P〉0.05).Co-expression of Livin and Mcm3 showed a positive correlation with both NP different stages and NP recurrence rate.Conclusion Over-expression of Livin maybe play a more important role in pathogenesis of NP than Mcm3.Livin and Mcm3 may be reference indexes for pre-judgement of NP recurrence.
出处 《山东大学学报(医学版)》 CAS 北大核心 2012年第5期112-115,123,共5页 Journal of Shandong University:Health Sciences
关键词 鼻息肉 细胞凋亡 LIVIN 微小染色体维持蛋白3 免疫组织化学 Nasal polyps Apoptosis Livin Minichromosome maintenance protein 3 Immunohistochemistry
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  • 1Ma L,Huang Y,Song Z,et al.Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathw ay[J].Cell Death Differ,2006,13(12):2079-2088.
  • 2Kageshita T,Kuwahara K,Oka M,et al.Increased ex-pression of germinal center-associated nuclear protein(GANP)is associated with malignant transformation of melanocytes[J].J Dermatol Sci,2006,42(1):55-63.
  • 3中华医学会耳鼻喉分会 中华耳鼻喉科杂志编辑委员会.慢性鼻窦炎鼻息肉临床分型分期及内窥镜鼻窦手术疗效评定标准(1997年/海口).中华耳鼻喉科杂志,1998,:134-134.
  • 4支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案)[J].中华结核和呼吸杂志,2008,31(3):177-185. 被引量:2518
  • 5Hsu M C,Shun C T,Liu C M.Increased epithelial cell proliferation in nasal polyps[J].J Formos M ed Assoc,2002,101(3):227-229.
  • 6庄夏衍,王挥戈.鼻息肉组织中各种浸润细胞的意义及相互间的作用[J].山东大学耳鼻喉眼学报,2010,24(2):47-54. 被引量:5
  • 7董震,关桂梅,常万龙.鼻息肉组织中细胞增殖与凋亡相关基因蛋白的表达及意义[J].中华耳鼻咽喉科杂志,2000,35(6):429-431. 被引量:29
  • 8Gazzaniga P,Gradilone A,Giuliani L,et al.Expression and prognostic significance of Livin,Survivin and other apoptosis-related genes in the progression of superficial bladder cancer[J].AnnOncol,2003,14(1):85-89.
  • 9Ha S A,Shin S M,Namkoong H,et al.Cancer-associ-ated expression of minichromosome maintenance3gene in several human cancers and its involvement in tumori-genesis[J].Clin Cancer Res,2004,10(24):8386-8395.
  • 10Kato K,Toki T,Shimizu M,et al.Expression of repli-cation-licensing factors M CM2and M CM3in normal,hyperplastic,and carcinomatous endometrium:correla-tion w ith expression of Ki-67and estrogen and progester-one receptors[J].Int J Gynecol Pathol,2003,22(4):334-340.

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  • 1Buyukozturk S,elincik A,Asian I,et al.Mehotrexate:can it be a choice for nasal polypsis in aspirin exacerbated respiratory disease[J] .Asthma,2009,46:1037-1041.
  • 2Cho HW,Park SK,Heo KW,et al.Methotrexate induces apoptosis in nasal polyps via caspase cascades and both mitochondria-mediated and p38 mitogen-activated protein kinases/Jun N-terminal kinase pathways[J] .Am J Rhinol Allergy,2013,27:26-31.

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