鼻息肉中Livin及Mcm3的表达及其意义

Expression and significance of Livin and Mcm3 in nasal polyps

目的探讨凋亡抑制蛋白Livin和Mcm3即微小染色体维持蛋白3在鼻息肉中的表达水平及特点,以及与鼻息肉临床分型分期和术后复发率的相关性。方法采用免疫组化SP法及计算机图像分析系统,检测40例单纯鼻息肉患者及6例正常钩突黏膜中Livin及Mcm3的表达,并与鼻息肉临床分期及术后复发率进行关联性分析。结果 Livin在鼻息肉与正常黏膜对照组之间的表达差异具有统计学意义(P<0.05)。Mcm3在鼻息肉与正常黏膜对照组之间的表达差异无统计学意义(P>0.05)。Livin、Mcm3联合表达强度与鼻息肉临床分型分期之间呈正相关关系(R's=0.606,P<0.05);Livin、Mcm3联合表达强度与鼻息肉术后复发率之间呈直线正相关关系(R=0.958 8,t=4.7779,P<0.05)。结论 Livin过度表达所致细胞凋亡受抑制在鼻息肉腺体发生发展的过程中可能具有重要作用,而Mcm3标志的鼻息肉细胞增殖活性的提高在其发病机制中可能处于一个相对次要的地位。Livin及Mcm3联合检测可作为预测鼻息肉患者术后复发率的参考指标。

Objective To explore expressions of Livin and Mcm3 in nasal polyps（NP）,and to investigate their relationships with NP′s clinical stages and recurrence rate.Methods Expressions of Livin and Mcm3 were detected in 40 cases of NP and 6 cases of normal mucosa of the uncinate process by immunohistochemistry and the image analytical system.Results Positive expression of Livin between NP and normal mucosa was statistically different（P〈0.05）,while Mcm3 was not（P〉0.05）.Co-expression of Livin and Mcm3 showed a positive correlation with both NP different stages and NP recurrence rate.Conclusion Over-expression of Livin maybe play a more important role in pathogenesis of NP than Mcm3.Livin and Mcm3 may be reference indexes for pre-judgement of NP recurrence.