热休克蛋白60介导的TLRs信号转导模式和“危险信号”学说

Heat Shock Protein 60-mediated TLRs Signaling Mode and the "Danger Signal" Theory

Toll样受体(TLR)是一类通过识别保守的病原相关分子模式来触发机体抗感染免疫的跨膜受体家族,是固有免疫系统中必不可少的组分。热休克蛋白(HSPs)是一类高度保守的应激蛋白,参与蛋白的折叠、转运、定位及降解等重要生命过程。近年来研究发现HSP90、HSP70、HSP60等分子还可作为组织细胞损伤的危险信号,引发机体固有免疫和炎性反应,尤其是HSP60被证实可作为TLR的内源性配体参与机体的免疫机制。

Toll-like receptors（TLRs）belong to one of the families of trans-membrane receptors and act as key sensors to detect conservative pathogen-associated molecule patterns.They are essential to initiate defensive immune responses and therefore constitute indispensable parts of the innate immune system.The heat shock proteins（HSPs）are highly conservative stress proteins involved in critical activities such as protein folding,transportation,localization and degradation.Recent studies demonstrate that HSPs are capable of serving as ＂danger signals＂ for tissue injury and triggering the innate immunity as well as inflammatory response.In particular,HSP60 is proved to function as the intrinsic ligands of TLRs,evoking the essential signaling pathway to induce the immune responses.