急性冠状动脉综合征与急性脑梗死缺血修饰白蛋白的对比研究

Comparative Study of Ischemia Modified Albumin in Acute Coronary Syndrome and Acute Cerebral Infarction

目的对比研究急性冠状动脉综合征(ACS)与急性脑梗死(ACI)患者血清缺血修饰白蛋白(IMA)的变化,以探讨IMA对ACS的诊断价值。方法检测对照组人群及发病12 h内ACI、不稳定型心绞痛(UA)、急性心肌梗死(AMI)患者血清IMA、肌酸激脢(CK-MB)及肌钙蛋白T(cTnT)值。结果 UA及AMI组患者血清IMA均显著高于对照组(P<0.01),UA组cTnT及CK-MB与对照组无显著差异。ACI患者血清IMA值显著高于对照组(P<0.01),但均显著低于UA及AMI组。结论UA及AMI患者血清IMA均显著升高,提示IMA形成可能与心肌缺血有关,而非心肌细胞坏死所致。IMA可作为诊断ACS的标志物,但因ACI患者IMA也升高,故IMA诊断ACS缺乏特异性。

Objective To explore the IMA for the diagnosis of ACS through.comparative study of the change of ischemia modified albumin（IMA）in acute coronary syndrome（ACS）and acute cerebral infarction（ACI）patients.Methods IMA,ceatine kinase MB（CK-MB）,cardiac troponin T（cTnT）values of acute cerebral infarction（ACI）,unstable angina（UA）,acute myocardial infarction（AMI）patients within 12 hours of onset and the control group were detected.of.Results IMA of UA and AMI patients were significantly higher than the control group（P0.01）,cTnT and CK-MB of UA group had,no significant difference to the control group;serum IMA in ACI patients were significantly higher than the control group（P0.01）,but were significantly lower than the UA group and AMI group.Conclusion IMA increased in UA patients and AMI patients,which indicates IMA formation may be associated with myocardial ischemia,and not the result of myocardial necrosis;IMA can be used as an ACS marker,but is lack of specificity because IMA increase also happen in ACI patients.