人血浆■_2-巨球蛋白制品的巴斯德消毒

Pasteurization of Human plasma α_2-Macroglobulin Preparation

以40g/dl 浓度的木糖醇为稳定剂,对 a_2-巨球蛋白(a_2M)制品进行了巴斯德消毒,以减少临床输用时传播艾滋病和肝炎等病毒性疾病的危险。经60℃ 10小时加热处理后的 a_2M 制品,仍充分保留其结合胰蛋白酶生物活性和免疫学反应性,且未测出有新抗原形成。其电泳表现及在家兔体内的代谢速率与加热前比较均未见不同,提示仍保持其良好的天然性。

The α_2-macroglobulin(α_2M)pre- paration was pasteurized,using 40g/dl of xylitol as a stabilizer,to reduce the risk of transmission of the viral diseases such as AIDS and hepatitis during the clinical trans- fusion.The α_2-M preparation,treated by heating at 60℃ for 10 hours, can still preserve fully its trypsin- binding biological activity and im- munological reactivity,and no new antigens were detected,which had the behavior in eleetrophoresis and the catabolic rate in rabbit that were not different from those of the un- heated samples,indicating that the pasteurized α_2-M preparation still keeps its good native properties.