枢丹、胃复安预防大剂量顺铂化疗所致呕吐的临床对比

Clinical effect of zudan and metoclopramide on confroling vomiting caused by cisplatin

目的 观察枢丹的止吐疗效和毒性。方法 对 2 0例接受大剂量顺铂化疗的患者 ,采用随机自身对照的方法 ,比较枢丹与胃复安的疗效和毒性。结果 枢丹能有效预防顺铂所致的恶心、呕吐 ,其止吐疗效优于胃复安 ,两药的止吐有效率分别为 70 %和 30 % ,完全缓解率分别为 5 5 %和 10 % ,两药的疗效统计学差异明显。结论 枢丹为肿瘤化疗安全、有效的止吐药。

Objective: To compare the clinical effect of zudan and metoclopramide on controling vomiting caused by cisplatin. Methods: 20 patients were randornly divided into two groups: group BA (n=10) and group AB (n=10).Zudan and metoclopramide were respectively given to them in different phases. The curative effect and side effect were observed. Results: The effective rate was 70% for zudan,30% for metoclopramide,and the side effect of zudan hadn't been observed. Conclusion: These results suggest that zudan may be more effective and safer than metoclopramide.