异种移植中的移植物抗宿主病

XENOGENEIC GRAFT-VERSUS HOST DISEASE

目的 了解异种移植物抗宿主病 (GVHD)的组织学特点 ,与同种 GVHD的区别及异种脾脏移植的关系。方法 对近十年来有关异种移植中 GVHD的特点及其与同种 GVHD区别的文献进行检索、综述。结果异种 GVHD由于共刺激信号、粘附分子的不匹配及所识别抗原的差异 ,其发生发展速度、组织学特点等均与同种GVHD不同。受体脾切除加异种脾移植有利于异种 GVHD的发生。结论 可利用异种 GVHD模型来观测异种移植排斥反应及检测异种供器官抗原相似性。

Objective\ To evaluate the histological characteristics of xenogeneic graft versus host disease(GVHD), and to differentiate it from the allogeneic GVHD.Methods\ The original articles related to the characteristics of xenogeneic GVHD and the relationship between xenogeneic GVHD and allogeneic GVHD were widely reviewed in the past decade.Results Xenogeneic GVHD was different from allogeneic GVHD in the speed of development, position and features of pathological changes, due to the incompatibility of common simulative signals, adhesive molecules and difference of antigens. Xenogeneic spleen transplantation could induce xenogeneic GVHD. Conclusion\ Xenogeneic GVHD can be used as a model to mimic rejection in xenotransplantation and to evaluate the compatibility of xenotransplantation.