中心性浆液性脉络膜视网膜病变OCT与mfERG图像的相关性

Correlation between OCT and mfERG assessment in central serous chorioretinopathy

目的利用光学相干断层扫描（OCT）与多焦视网膜电图（mfERG）分析中心性浆液性脉络膜视网膜病变（csc）患者的OCT与mfERG图像的关系。方法横断面研究。应用德国CarlZeissCirrusHD-OCT及美国EDI VERIS Science^TM4．9视诱发反应图像系统对40只急性期CSC眼（40例）进行检查。将CSC患者OCT黄斑厚度图三个环的视网膜平均厚度与相对应的多焦视网膜电图（mfERG）的1＋2环、3环、4环的N1、P1波的平均反应密度和峰时间进行比较，并将黄斑区体积、总的黄斑中心凹的厚度、视网膜下液高度、视网膜下液范围和中心凹神经上皮厚度与mfERG6个环的N1、P1波反应密度和潜伏期比较分析。采用Spearman秩相关进行数据分析。结果CSC患者OCT内环、中环、外环的视网膜平均厚度与mfERG1＋2环、3环、4环的N1、P1波的峰时间呈正相关。黄斑区体积、总的黄斑中心凹的厚度、视网膜下液高度和视网膜下液范围与mfERG的N1、P1波反应密度和峰时间有显著的相关性。结论CSC患者的黄斑平均视网膜厚度及积液情况与mfERG之间有一定的相关性，可用OCT测量黄斑区视网膜下液的积液量，尤其是用积液范围来评估黄斑区视网膜功能的改变。OCT与mfERG的检测可以综合评价CSC患者的形态与功能的变化。

Objective To evaluate the correlation between functional and anatomical assessments with muhifocal eleetroretinography （mfERG） and optical coherence tomography （OCT） in patients with acute central serous ehorioretinopathy （CSC）. Methods Cross-Sectional study. Forty eyes of 40 patients with acute CSC underwent Cirrus HD-OCT （Carl Zeiss） and VERIS ScienceTM 4.9 （EDI） visual evoked response imaging system examinations. Correlation analyses were performed between the central area of the OCT corresponding to the summed responses from the first and second rings measured by mfERG, the second and third areas of the OCT corresponding to the third and fourth of the six concentric rings measured by mfERG, OCT parameters of the maeular volume, total central foveal thickness （CFI）, central subretinal fluid （SRF） thickness, SRF diameters, and central retinal thickness corresponding to the six concentric rings of the mfERG N1 and P1 response amplitudes and latencies. Results An increased macular thickness in the three areas of the OCT correlated to prolonged implicit times in the corresponding rings of the mfERG. OCT parameters of the macular volume, total CFT, SRF thickness, and SRF diameters were significantly correlated to the six concentric rings of the mfERG N1 and P1 response amplitudes and latencies. Conclusion The macular thickness in the three areas and the amount of the central subretinal fluid of the OCT are significantly correlated with the mfERG parameters. The amount of SRF in eyes with CSC, especially SRF diameters, can be measured to assess macular function. OCT and mfERG can synthetically evaluate functional and anatomical assessments in CSC.