不同时期经皮注射自体骨髓对尺骨干骨折愈合的影响

Effect of subcutaneous injection of autologous bone marrow for ulna fracture healing

目的观察不同时期经皮注射自体骨髓对尺骨干骨折愈合的干预效果,以明确为预防骨折不愈合而采用经皮注射自体骨髓的时机选择。方法对200例尺骨干骨折患者行钢板内固定术,随机分组,40例为对照组;治疗组分为4个亚组(分别为A、B、C和D组),各40例,分别于术后0.5、1.0、2.0和3.0个月时开始在骨折端经皮注射自体骨髓,观察自体骨髓对骨折愈合的影响。结果经过统计学分析,术后6个月时A、B两组骨折愈合率相比,无显著性差异(P>0.05),但高于其他各组(P<0.05);C组、D组及对照组术后6个月时骨折愈合率相比,无显著性差异(P>0.05)。结论在临床上,对于骨折不愈合率较高的部位,为预防骨折不愈合,术后可尽早进行经皮注射自体骨髓。

Objective To observe the effect of autologous bone marrow injection for ulna fracture union at different time points,and explore the opportunity to perform auto-bone marrow injection in preventing bone non-union.Methods Two hundred patients with ulna fracture were subjected to plate internal fixation,and randomly divided into control group（n=40） and experimental group（n=160）.The patients in the experimental group were subdivided into four subgroups（groups A,B,C and D）,and auto-bone marrow was subcutaneously injected on the postoperative month 0.5,1,2,and 3,respectively.Results Six months after internal fixation,bone union rate had no significant difference between subgroup A and subgroup B（P0.05）,and that in subgroups A and B was higher in other groups（P0.05）.The bone union rate had no significant difference between subgroups C and D with control group（P0.05）.Conclusion To prevent bone non-union,autologous bone marrow can be subcutaneously injected as early as possible after internal fixation.