运动与心脏能量代谢

Exercise and Cardiac Energy Metabolism

心脏的功能取决于高效率能量代谢。不同状态下(病理和生理),心脏能量代谢会发生变化。正常健康的心脏,脂肪酸是主要的底物;疾病的心脏,糖的利用可能更为有益;在运动状态下,乳酸代谢增加。运动诱导心肌肥大能量代谢正常,底物来自于脂肪代谢。特定的核受体转录因子和共激活剂调节与能量代谢底物选择发生变化相关基因的表达。但是涉及到运动益处的确切机制并不清楚,须进一步研究。

Cardiac function depends on efficient energy metabolism. Under different condition （Pathology and physiology）, cardiac energy metabolism will change. For healthy heart, fatty acids are the major substrates, while the diseased heart, glucose utilization may be more useful. Under the exercise condition, lactate metabolism in- creases. Exercise induced myocardial hypertrophy of energy metabolism in normal and the substrate from fat me- tabolism. Specific nuclear receptor transcription factor and co - activator adjustment and energy metabolism sub- strate selection change related gene expression. However, the exact mechanism related to exercise benefits is not clear and need further study.