蓝芩口服液治疗手足口病普通患儿的疗效观察

目的观察蓝芩口服液对手足口病普通患儿的治疗效果。方法长春市儿童医院2010年1月～2011年6月门诊诊断的240例手足口病普通病例患儿,随机分为对照组、单一治疗组和联合治疗组,每组80例,在常规退热等对症治疗基础上,分别给予利巴韦林气雾剂、蓝芩口服液、利巴韦林气雾剂联合蓝芩口服液治疗,观察3组的治疗效果。结果蓝芩口服液治疗组退热时间、疱疹消退时间、手足皮疹消退时间及总有效率与利巴韦林气雾剂对照组差异无统计学意义(P>0.05),但二者联合治疗能明显缩短退热时间、疱疹和皮疹消退时间,提高总有效率(P<0.05),联合治疗组的退热时间、疱疹消退时间及手足皮疹消退时间分别为2d、3d和4.5d左右,而单一治疗组和对照组相应时间分别为3.5d、5d和6d左右。两种药物均未见明显不良反应(P>0.05)。结论蓝芩口服液临床治疗手足口病普通病例安全、方便、有效。

Objective To observe the effects and safety of Lanqin oral liquid on children with mild hand-foot-mouth disease.Methods Two hundred and forty children with milder hand-foot-mouth disease were randomly allocated into three groups,treated with ribavirin spray,Lanqin oral liquid,and ribavirin spray combined with anti-virus oral liquid,respectively.Results There were no differences in defervescence,regression time of herpes and erythra,and the total efficacy rate between Lanqin oral liquid group and ribavirin spray control group（P0.05）.But ribavirin spray combined with Lanqin oral liquid treatment could shorten the defervescence and regression time of herpes and erythra,increase the total efficacy rate（P0.05）.There were no apparent side effects in both drug treatment groups（P0.05）.Conclusion Lanqin oral liquid is safe,simple and effective in the treatment of children with milder hand-foot-mouth disease.