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心肌梗塞患者载脂蛋白E基因多态性研究及其对临床与血脂代谢的影响 被引量:2

Study On Apolipoprotein E Gene Polymorphism of Myocardial Infarction Patients and its Effection on Clinical Course of the Patients and Plasma Lipid Metabolism
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摘要 目的:研究载脂蛋白(Apo)E基因多态性对心肌梗塞发生、发展及预后的作用及其对血脂水平的影响。 方法;应用聚合酶链反应-限制性片段长度多态性检测方法,测定104例心肌梗塞患者(心肌梗塞组)和180例正常对照者(对照组)的Aop E基因型;并按常规方法测定血脂水平。 结果:共检测出 5种 Apo E基因型,分别为 Apo E3/3、Apo  E3/2、Apo E4/3、Apo E4/2及 Apo E4/4。心肌梗塞组Apo E4/3基因型和ApoEε4等位基因频率均显著高于对照组(P<0.01);心肌梗塞组总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)高于对照组(P<0.05);心肌梗塞组泵功能Ⅲ~Ⅳ级患者ApoE4/3基因型频率高于泵功能Ⅰ~Ⅱ级患者(P<0.05);Apo Eε4等位基因具有升高TC、LDL-C的作用,Apo Eε2等位基因则有降低TC、LDL-C的作用。 结论:ApoE基因多态性与心肌梗塞的发生、发展和血脂的代谢水平密切相关;Apo Eε4等位基因可能是心肌梗塞重要的遗传标记,Apo E4/3亦影响心肌梗塞泵功能分级。 Objectives:To study the function of apolipoprotein E(Apo E)gene polymorphism on myocardial infarction(MI) and to evaluate the effect of Apo E gene polymorphism on plasma lipid levels. Methods:The Apo E genotypes of 104 MI patients and 180 healthy controls were determined by PCR-RFLP,other plasma lipid levels were measured by routine ways. Results:Five genotypes of Apo E,Apo E3/3,Apo E3/2,Apo E4/3,Apo E4/2 and Apo E4/4 were detected in our study. There were statistically significant differences in Apo E4/3 and ε4 frequencies between MI patients and controls (p<0.01 ). MI patients had higher plasma total cholesterol and low density lipoprotein cholesterol than controls (p< 0.05). Patients with pump funtion of class Ⅲ- Ⅳ had higher Apo E4/3 frequencies than those with better pump funtion (class Ⅰ - Ⅱ ). Apo Eε4 can increase plasma total cholestero(TC) and low-density lipoprotein cholesterol(LDL-C)lev- els,while Apo Eε2 decrease them. Conclusion:These results suggest that Apo E gene polymorphism is involved in occurrence of MI and affects plasma lipid levels;Apo Eε4 might be an important genetic factor of MI IApo E4/3 might have an effect in pump function of MI.
出处 《中国循环杂志》 CSCD 北大核心 2000年第2期72-74,共3页 Chinese Circulation Journal
基金 国务院侨务办公室(部级)重点学科科研基金!(项目编号1998175) 广东省医药科研立项资助!(编号1998567)
关键词 载脂蛋白E 基因多态性 心肌梗塞 血脂代谢 Apolipoprotein E Gene Polymorphism Myocardial infarction Lipid
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