葆乐辉对慢性阻塞性肺疾病患者肺功能的疗效观察

Observation of therapeutic effect of protheo on pulmonary function in patients with chronic obstructive pulmonary disease.

目的 了解无水茶碱控释片 (葆乐辉 )对慢性阻塞性肺疾病 (COPD)的肺功能疗效。方法 采用随机公开分组对照法 ,前瞻性比较口服葆乐辉与不服用葆乐辉对慢性阻塞性肺疾病患者肺功能的疗效。将患者分为治疗组 ( 3 1例 )及对照组 ( 3 1例 )。治疗组采用葆乐辉 40 0mg d进行 2个月的连续口服治疗。对照组 3 1例不服该药。服药前及服药后第 2个月末 ,分别测定肺功能。结果 治疗组肺功能的主要指标FVC、FEV1 及FEV1 FVC %较服药前及对照组明显改善 ,差异有显著性。结论 使用无水茶碱控释片 (葆乐辉 )治疗慢性阻塞性肺疾病 ,对其肺功能改善有肯定疗效。说明即使对可逆性不大的气流阻塞的COPD患者 ,葆乐辉也有肯定疗效 ,且葆乐辉为控释制剂 。

Objective In order to study the effect of protheo on pulmonary function in patients with chronic obstructive pulmonary disease. Methods Divide the patients randomly into two groups,the treated group(31 cases)and the control group(31 cases)and then compare prospectively the effects of protheo on pulmonary function in patients with chronic obstructive pulmonary disease.The treated group was given protheo orally 400 mg once a day for two months on end while the control group was not given protheo.Test their pulmonary function before their taking protheo and at the end of two months of their taking protheo respectively.Results The pulmonary function parameters of the treated group,including FVC,FEV 1 and FEV 1/FVC%,were apparently improved compared with those before the treated group's taking the medicine and those of the control group as well.Conclusion Administering protheo for chronic obstructive pulmonary disease has significant effect on the improvement of pulmonary function.This shows that even for those patients with COPD of small airflow block this medicine is helpful.Besides protheo is a kind of control releasing tablets.so patients′ compliance on it is clearly superior to that on common aminaphlini.