外周血白细胞计数与新生儿窒息后肾损伤的关系探讨

PRELIMINARY RESEARCH ON THE RELATIONSHIP BETWEEN WHITE CELL COUNTS IN PERIPHERAL BLOOD AND RENAL DAMAGE IN NEWBORN

目的 :探讨窒息后新生儿外周血白细胞计数与其伴发肾损伤的关系。方法 :在出生后 2 4小时内 ,对37例窒息新生儿 (轻度窒息 2 3例 ,重度窒息 1 4例 )和 9例正常新生儿血清BUN、Cr水平及外周血白细胞计数进行了检测。结果 :重度窒息组白细胞计数 ,BUN、Cr及肾损伤发生率明显高于轻度窒息组和对照组 ,肾损伤组外周血白细胞计数明显高于非肾损伤组 ,但Apgar评分明显低于非肾损伤组 ,相关分析表明 :外周血白细胞计数与BUN、Cr呈正相关 ,与Apgar评分呈负相关。结论 :外周血白细胞数升高与新生儿窒息后肾损伤密切相关 ,可作为窒息后肾损伤的一个独立危险因素。

Objective: To investigate the significance of increased white cell count of peripheral blood for postasphyxial renal damage in newborn . Methods: 37 newborns with asphyxia were divided into mild asphyxia group (23 cases) and serious asphyxia group (14 cases), 9 health newborns were regarded as control group . the level of BUN, Cr in serum , the count of white cell in peripheral blood and urinary routine were detected in postnatal 24 hours. Results: Serum BUN, Cr , the count of white cell and rate of renal injury in serious asphyxia group were found higher than those in the mild group; compared with non-renal injury group, the count of WBC was significantly increased , and Apgar's score was obviously decreased in renal injury group; the count of WBC in renal injury group was positively related to the seerum levels of BUN and Cr, While and negatively related to Apgar's score. Conclusion : The increased white cell count in peripheral blood plays an important role in postasphyxial renal damage in newborn ,which may be regarded as a risk factor in newborn renal damage induced by asphyxia.