不同麻醉方法对骨科患者认知功能的影响研究

Different Anesthetic Techniques on Cognitive Function in Patients with Orthopedic Research

目的探讨丙泊酚与七氟烷麻醉对骨科患者术后认知功能的影响。方法对我院2008年3月至2011年2月收治的接受骨科手术治疗的患者231例,随机分为实验组以及对照组.实验组患者采用丙泊酚麻醉,对照组采用七氟烷麻醉,并对两组患者相关指标进行判断。结果对两组患者POCD发生情况比较,其中实验组患者在3d内出现91例次,对照组出现162例次,两组患者有明显差异性(P<0.05);在术后1d以及6h比较中,两组患者的MMSE评分有明显的差异性(P<0.05)。对两组患者围手术期血流动力学、BIS以及皮质醇的变化比较,两组患者在不同时间比较,有明显差异性(P<0.05)。结论两种麻醉药物均可导致患者出现早期认知功能障碍但七氟烷的影响更为严重且维持时间更长。

Objective To investigate the propofol and sevoflurane anesthesia for orthopedic postoperative cognitive function.Methods The hospital in March 2008,admitted in February 2011 orthopedic surgery patients receiving 231 cases were randomly divided into experimental group and control group,the experimental group were treated with propofol anesthesia,sevoflurane anesthesia control group,and two groups of patients to determine the relevant indicators.Results The occurrence of POCD patients were compared to patients in the experimental 3d appeared in 91 cases times,second control group had 162 cases,two patients have significant differences（P0.05）;in 1d and 6h after comparison,two groups of patients with MMSE score significantly difference（P0.05）.The two patients in the perioperative its cycle,BIS,and compared the changes in cortisol,two more patients at different times,there are significant differences（P0.05）.Conclusion Both anesthetic drugs can cause cognitive dysfunction in patients with early,but more severe effects of sevoflurane and maintained longer.