慢性阻塞性肺疾病患者血清CRP、IL-6、IL-8、NO与肺功能关系的临床研究

Clinical Research of Relationship between Lung Function and Serum CPR, IL-6, IL-8 and NO in Patients with Chronic Obstructive Pulmonary Disease

目的探讨慢性阻塞性肺疾病(COPD)患者血清C反应蛋白(CRP)、白细胞介素-6、白细胞介素-8、一氧化氮(NO)与肺功能关系的临床意义。方法采集慢性阻塞性肺疾病急性加重期、缓解期患者和健康者外周血,检测血清CRP、IL-6、IL-8、NO水平,测定肺功能。结果血清CRP、IL-6、IL-8水平比较:急性加重期组明显高于缓解期组,缓解期组明显高于健康对照组,差异均有显着性(P<0.05);血清NO水平和肺功能指标(FEV1%、FEV1/FVC%)比较:急性加重期组明显低于缓解期组,缓解期组明显低于健康对照组,差异有显着性(P<0.05);COPD急性加重期血清CRP、IL-6、IL-8水平与FEV1/预计值%呈负相关(r=-0.812,P<0.05),血清NO水平与FEV1/预计值%呈正相关(r=0.437,P<0.05)。结论 COPD患者血清CRP、IL-6、IL-8、NO的水平与肺功能及病情变化密切相关,血清CRP、IL-6、IL-8、NO的变化可衡量COPD病情严重程度和判断患者的疗效及预后,CRP可作为COPD早期抗感染的参考指标之一。

Objective Explore the clinic significance of CRP,IL-6,IL-8,NO and pulmonary function in patients with COPD.Method Acquire peripheral blood of patients with COPD in acute exacerbation,in catabasis and healthy person.Measure the serum CRP,IL-6,IL-8,NO and lung function.Result Compare serum CRP,IL-6,IL-8： The group of AECOPD is significantly higher than the group of catabasis,and the group of catabasis is significantly higher than the group of healthy person（P0.05）;Compare the serum NO and lung function（FEV1%、FEV1/FVC%）： group AECOPD is lower than group catabasis,and group catabasis is lower than group healthy person,the difference are significant（P0.05）;The level of serum CRP,IL-6,IL-8 are negatively correlated to the value of FEV1/expected value%（r=-0.812,P 0.05）.The level of serum NO is positively correlated to the value of FEV1/expected value%（r=0.437,P0.05）.Conclusion The level of the serum CRP,IL-6,IL-8,NO and lung function are closely related to the changing of the patient’s conditions.Serum CRP,IL-6,IL-8 can be used to judgd the severity of the illness.They can also be used to estimate the curative effect and prognosis.CRP can be used as one of reference index in resisting infection in early stage of COPD.