氦氖激光血管内照射对急性脑梗塞患者血液流变学等的影响

The influence of He-Ne laser intravascular irradiation therapy on hemorrheology of acute cerebral infarction patients

目的 探讨低能量氦氖激光血管内照射 (ILIB)对急性脑梗塞的疗效及对血液流变学血脂和经颅多普勒 (TCD)的影响。方法 对 142例急性梗塞患者随机分ILIB治疗组 72例和对照组70例 ,比较两组治疗 2 0d前后的血液流变学、血脂指标的变化及疗效 ,对其中大脑中动脉梗塞区两组各 2 4例治疗前后的TCD中的大脑中动脉 (MCA)、大脑前动脉 (ACA)及大脑后动脉 (PCA)的平均血流速度 (Vm)进行了比较。结果 ILIB治疗组疗效明显优于对照组 ,两组治愈显效率分别为 39%和2 9 % ,总有效率为 96 %和 80 % (χ2 =4.5 6 9,P <0 .0 5 )。其血液流变学和血脂中总胆固醇 (CHO)、载脂蛋白B(APOB)指标 ,治疗前后对比及与对照组比较 ,差异均有显著性 (P <0 .0 5或 0 .0 1)。TCD检测显示大脑中动脉供血区梗塞 ,ILIB组治疗后的变化为MCA的Vm增加 ,ACA的Vm减慢 ,ILIB组治疗后的Vm基本接近同龄健康人组。结论 ILIB能显著提高急性脑梗塞患者疗效 ,能改善血液流变学 ,部分血脂及血液动力学指标。

Objective To detect the effect,hemorrheology,and transcranial Doppler sonarography of low energy He-Ne laser intravascular irradiation therapy for acute cerebral infarction (ACI) patients.Methods 142 cases with ACI were divided into therapeutic group(n=72) and control group(n=70).The first group patients were treated with low energy He-Ne laser intravascular irradiation and the second group received Weinaolutong drug therapy.Before and after the 20 days of treatment,the hemorrheology,blood lipid and clinical effects were observed and compared.Among them,24 cases of therapeutic group and 24 cases of control group with middle cerebral artery(MCA) infarction were observed to find and compare the mean peak blood-flow velocity of MCA,anterior cerebral artery(ACA) and posterior cerebral artery(PCA) by transcranial Doppler sonarography.Results The excellent rate of therapeutic group and control group was 39% and 29% respectively,the effective rate was separately 98.6% and 80%(P<0.05).While there were significant differences in total cholersterol and apoprotein B at pre-and post-treatment or between the two groups(P<0.05～0.01). Of transcranial Doppler sonarography,the mean peak blood-flow velocity of MCA increased and that of ACA decreased after laser treatment,it was nearly similar to healthy adults.Conclusion The study suggests that this therapy can receive a better effect,improve the blood lipid and hemorrheology parameters for ACI patients.