慢性肺心病T淋巴细胞亚群、NK细胞活性及红细胞免疫功能的初步观察

THE CLINICAL OBSERVATION OF T LYMPHOCYTE, NK ACTIVITY AND ERYTHROCYTE LMMUNIZATION FUNCTION IN PATIENTS WITH PULMONARY HEART DISEASE

目的：了解慢性肺心病T淋巴细胞亚群、NK细胞活性及红细胞免疫功能变化及临床意义。方法：测定30例肺心病患者急性发作期和缓解期外周血T淋巴细胞亚群、NK细胞活性及红细胞免疫功能，并与25例正常人对照。结果：肺心病患者急性发作期CD3、CD4、CD4／CD8比值、C3bRR及NK细胞活性均明显低于正常人（P＜0．01），CD8则明显高于正常人（P＜0．01），肺心病伴明显缺氧和高碳酸血症者变化最明显。治疗缓解期上述指标均有不同程度的恢复，但与正常人相比仍有差异（P＜0．05）。结论：肺心病病人存在原发性免疫功能障碍，测定T淋巴细胞亚群、NK细胞活性及红细胞免疫功能对了解肺心病病人免疫力、指导治疗有一定临床意义。

Objective To evaluate the changes and clinical significance of T Lymphocyte, erythrocyte, erythrocyte immunization and serum levels of immunoglobulin in patients with pulmonary heart disease. Method The Tlymphocyte, NK activity and erythrocyte immunization function of 30 patients with pulmonary heart disease in acute and remission stage and 25 normal subjects were determined. Result The CD3, CD4, CD4/CD8, C3bRR and activity of NK cell decreased, CD8increased significantly in acute stage of patents with pulmonary heart disease (P < 0. 01 ). In remission stage all the changes recovered in different degree but were still abnormal. Conclusion There are primary functional disorders in patients with pulmonary heart disease. The determination of Tlymphocyte,NK activity and erythrocyte immunization fumction in patients with pulmonary heart disease can realize the immunity of patients and direct the treatment.