微波心肌血运重建术后心肌孔道组织学的实验观察

Histologic Observation of Microwave-Induced Transmyocardial Channel Experiments

目的:探讨微波心肌血运重建术的可行性。方法:在家兔左心室进行微波心肌打孔,设立正常对照组、针刺组及实验组。对照组行单纯开胸探查术。针刺组在开胸心脏跳动下,进行左心室壁穿刺3～5孔,实验组在同样条件下行左心室针状微波辐射器穿刺后发射微波,发射剂量为30W,辐射时间3秒。对家兔饲养30、60天后处死,观察心肌孔道转归、孔道周围心肌组织光镜及电镜下的改变。结果:针刺组术后60与30天相比,其心肌内孔道横径、面积明显缩小,实验组与针刺组相比,其孔道横径、面积也明显缩小。实验组术后60、30天,电镜下观察到孔道周围心肌组织损伤有明显恢复趋势,其孔道内仍伴有多量新生微血管。结论:针状微波辐射器发射微波对兔心肌打孔,在术后30天至60天可产生血管重建。

Objective:To evaluate the effects of microwave-created channels in the left ventricular wall for transmyocardial revascu-larization. Methods:35 rabbits were divided randomly into 3 groups:normal control,acupuncture with pure needle and ex-periment group. The histological changes under the optical microscope and the electronic microscope were observed at 30 d and 60 d after cardiac surgery. Results: In acupuncture group the internal diameter and area of channel were gradually be-coming smaller. Although the channeb in experimental group were smaller than the pure needle group,many new microves-sels were seen after 30 d and 60 d. Conclusion:Microwave could be used to create small channels through myocardium and to induce many new microvessels.