糖尿病合并症与蛋白激酶C

Diabetic complications & protein kinase C

糖尿病 (DM )可引起体内各系统的合并症。实验研究表明 ,二酰基甘油 (DAG) 蛋白激酶C(PKC)通路的活动增加与DM合并症的产生密切相关 ,可能是DM时多种生化指标引起合并症产生的最后的细胞内共同通路。在已知的 11中PKC亚型中 ,PKC β和

Hyperglycemia can activate protein kinase C (PKC), and the activity of PKC was increased in most of diabetic tissues. Studies suggested that DAGPKC pathway is the final intracellular common pathway through which the diabetic complications were induced by many factors. Among the PKC isoforms, PKCβ and ε were most likely related with diabetic complications.