醋酸钙与肾结石研究初探

Primary study on the relationship between calcium acetate and kidney stone

目的 通过给动物补充适量的醋酸钙以及在乙二醇引起体内草酸代谢异常的情况下补充同等剂量的醋酸钙 ,对以醋酸钙作为补钙剂与肾结石之间的关系进行研究探讨。方法 采用 6 0只Wistar大鼠作为受试动物 ,分别给予醋酸钙或碳酸钙以及用乙二醇诱发肾结石的同时给予醋酸钙或碳酸钙 ,饲养 8wk后处死动物 ,分别对其肾脏发生结石的情况加以观察。结果 本实验条件下补充适量的钙剂 ,在生理情况正常的动物中没有发现肾结石 ;而在人为造成草酸代谢异常的情况下 ,补钙使结石数量有所增加。结论 正常补充钙制剂不会引起肾结石 ;

AIM To investigate the relationship between calcium acetate as supplement and kidney stone by giving calcium acetate to the experimental rats both with normal physiological condition and with abnormal oxalate metabolism. METHODS Observations of the stone formation were made after 8 week feeding of Wistar rats with calcium acetate and classical calcium supplementcalcium carbonate. RESULTS In the experimental condition, calcium acetate did not induce kidney stone in rats with normal physiological condition, however, an increased risk was observed in the animals with abnormal oxalate metabolism. CONCLUTION Calcium acetate is a safe calcium supplement when it is used properly; oxalaterich food should be avoided at the time of calcium supplementation.