氨丁苯酞对血小板聚集功能的影响

Inhibitory effect of GZ-02 on rat platlet aggregation

目的 观察氨丁苯酞 (GZ 0 2 ) ,丁苯酞 (NBP)的结构衍生物对血小板聚集功能的影响。方法 参照Tamura法 ,观察GZ 0 2对局部脑缺血大鼠血小板聚集率的影响 ,并用比蚀法测定了GZ 0 2体内和体外给药对AA、ADP和胶原诱导的血小板聚集率的影响。结果 GZ 0 2能明显降低局部脑缺血大鼠血小板聚集率的异常增高 ,体内体外条件下均能明显抑制AA诱导的血小板聚集。结论 实验证明GE 0

AIM To investigate the effect of GZ02,a structure derivative of NBP, on rat platelet aggregation. METHODS Focal cerebral ischemia was produced by permenent occlusion of the proximal of the left middle cerebral artery (MCAO); Platelets aggregation induced by AA、ADP and collagen were studied by turbidimetry in rat blood, ex vivo and in vitro. RESULTS GZ02 40,80 and 160 mg·kg -1 significantly inhibited abnormal increase of platelet aggregation caused by MCAO. GZ02 selectively inhibited the platelet aggregation induced by arachidonic acid (AA), but not by ADP and collagen. CONCLUSION GZ02 has inhibitory effects on platelet aggregation.