Quinacrine不同给药途径对家兔血药浓度的影响

Comparative study affecting plasma concentration of quinacrine by giving the drug in uterus and other ways

目的 研究 quinacrine经不同途径给药的血药浓度 ,了解 quinacrine经阴道向子宫内给药绝育 (quinacrine女性非外科绝育法 )可能产生的毒副反应。方法 以兔为模拟对象 ,用荧光分析法分别测定宫腔内缓释给药、静脉、口服和输卵管内注射等 4种不同途径给quinacrine的血药浓度变化。结果 血药浓度峰值以静脉给药法最高 ,宫腔内缓释给药法最低。宫腔内缓释给药法的血药浓度水平接近其他给药方法血药浓度水平的残余浓度。血药浓度下降的起点静脉法在给药后立即产生 ,口服法在给药后 8h出现 ,输卵管内注射法见于给药后 4h ,而宫内缓释法则可维持到 7d。结论 从是否产生全身性的毒副反应的角度看 ,quinacrine宫腔内缓释给药法比口服法低 。

AIM To study and investigate the side reactions of quinacrine given as female sterilization through uterus by observing the plasma concentrations of quinacrine as sterilization given through different ways METHODS Rabbits were taken as mock object The plasma concentrations of quinacrine given through uterus, vein, os, and injection in fallopian tube were determined separately with fluorescence analysis RESULTS The peak value of plasma concentration is the highest by iv, but is the lowest byre leasingslowlyinuterus CONCLUSION Itissafe thatquinacrineisusedinnosurgicalfemalesteriliza tionthroughreleasingslowlyinuterus