胃肠疾病中的环氧合酶研究进展

Research of Cyclooxygenase in the Gastrointestinal Diseases

环氧合酶（cyclooxygenase,COX）是调节前列腺素释放的关键酶,目前已确定和发现的环氧合酶亚型主要是结构型环氧合酶-1（COX-1）与诱导型环氧合酶-2（COX-2）.近年来,对COX-1、COX-2的研究方兴未艾.随着认识的深入,对COX-1、COX-2的研究已不仅仅局限在催化产生保护性前列腺素上,其在胃肠疾病中的作用也日益受到重视.该文就COX在胃肠疾病中的不同效应及中医药在其中的预作用进行综述.

Cyclooxygenase（COX） is a key enzyme in regulating the release of prostaglandin. Cyclooxygenase-l（COX-1） and cyclooxygenase-2（COX-2） have been identified as the two main cyclooxygenase isoforms.In recent years,the COX-1 and COX-2 have become the research hotspot.With in-depth understanding of the COX-1 and COX-2,research has not only been limited in catalyzing and generating protective prostaglandins,but also on their significant function in treating gastrointestinal diseases.In this paper,the effects of COX in treating gastrointestinal diseases and the intervention treatment of traditional Chinese medicine are reviewed.