甘草附子汤联合玻璃酸钠注射治疗膝骨关节炎60例

Oral Gancao Fuzi Decoction combined with injection of sodium hyaluronate in the treatment of 60 patients with knee osteoarthritis

目的:观察甘草附子汤内服、玻璃酸钠关节腔内注射和两者联合3种方法治疗膝骨关节炎的临床疗效。方法:将60例患者随机分为甘草附子汤内服组,玻璃酸钠关节腔内注射治疗组和联合治疗组,每组20例。对各组患者LE-QUESNE指数总积分改变值、视觉模拟评分值(VAS)进行治疗前后比较及组间比较。结果:3组均可明显缓解疼痛,改善患者功能活动,提高患者日常生活能力。3组患者治疗前后症状和体征、LEQUESNE指数积分对比、视觉模拟评分值等比较差异均有统计学意义(P<0.01),治疗后明显优于治疗前。中药组与玻璃酸钠组组间疗效比较差异无统计学意义(P>0.05),联合治疗组的疗效优于单一治疗组(P<0.05)。结论:应用甘草附子汤内服结合玻璃酸钠关节腔注射治疗较单一疗法对患者缓解疼痛、改善功能疗效更好。

Objective：To observe the clinical curative efficacy of Gancao Fuzi Decoction,intraarticular injection of sodium hyaluronate and the combined therapy of the two methods in treating knee osteoarthritis.Methods：Sixty patients with knee osteoarthritis were randomized into Gancao Fuzi Decoction group,intraarticular injection of sodium hyaluronate group and combined therapy group,20 in each group.The Lequesne index and VAS scale were recorded and compared.Results：There were improvements in pain,daily function and activity of daily living in three groups.The differences in symptoms and signs,Leuesne index and VAS scale before and after treatment were significant（P0.01）.There was no significant difference between Gancao Fuzi Decoction group and intraarticular injection of sodium hyaluronate group（P0.05）.The combined therapy group showed better effect than the other two groups（P0.05）.Conclusion：Oral administration of Gancao Fuzi Decoction combined with intraarticular injection of sodium hyaluronate is effective in relieving pain and promoting function.