摘要
目的:探讨子宫内膜异位症患者在位内膜黏蛋白-1(MUC1)的表达变化及意义。方法:采集子宫内膜异位症及输卵管因素不孕的54例患者的在位子宫内膜,采用免疫组织化学方法检测内膜MUC1的表达;分析内异症不同疾病分期与MUC1表达变化的相关性以及与对照组的差异性。结果:子宫内膜异位症患者在位内膜MUC1在不同月经周期的表达差异不明显,而与对照组比较表达明显减少;MUC1表达与内异症不同疾病分期存在相关性。结论:子宫内膜异位症患者在位内膜MUC1表达的减少与内异症疾病分期有密切相关性,可能是导致不孕的原因之一。
Objective：Investigate the expression and significance of MUC1 in endometriosis endometrium. Methods：Immunohistochemical were utilized to determined the expression of MUC1 in eutopic endometrial obtained from the operated patients with endometriosis（EMs group） and the patients with oviduct block（control group） respectively.Then to analyze its relationship between MUC1 expression and disease stages,distinguishe their difference with control group. Results：there was no difference in levels of MUC1 expression with menstrual cycle in endometriosis.However,significantly decreased compared with control group.This decreased tendency was also observed with advanced disease stages. Conclusion：there is close correlation between advanced stages and level of MUC1 in endometriosis endometrium,which may be the factor of infertility with endometriosis.
出处
《中国妇幼保健》
CAS
北大核心
2012年第14期2181-2183,共3页
Maternal and Child Health Care of China
基金
苏州市科技支撑项目〔sys201064〕
