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重度子痫前期患者胎盘组织中miR-21的表达及其临床意义 被引量：4

The expression and its clinical significance of miR-21 in placenta from severe preeclampsia patients
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摘要 目的:检测miR-21在重度子痫前期患者与正常孕妇胎盘组织中的表达差异。方法:收集2011年1月～2011年8月在江西省妇幼保健院产科行剖宫产的16例重度子痫前期患者和16例正常妊娠妇女的胎盘组织,通过实时荧光定量PCR技术检测胎盘组织中miR-21的表达水平。结果:miR-21在重度子痫前期患者胎盘组织中表达水平明显升高,为正常对照组表达水平的2.02倍(P<0.05)。结论:miR-21在胎盘组织中的表达水平可能与子痫前期的发生发展病理过程存在一定相关性。 Objective：To investigate differential expression of miR-21 in the placenta between severe preeclampsia and normal pregnancy. Methods：Placentas were obtained during elective cesarean section from patients with severe preeclampsia（n=16） and normal pregnancy（control group,n=16） from January to August 2011.The miR-21 expression were assessed by real time PCR. Results：The expression of miR-21 were abnormal in the placentas of preeclamptic pregnancy.miR-21 was upregulated in PE（2.02fold） compared with control group. Conclusion：The abnormal expression of miR-21 may involve in the generation and pathogenesis of preeclampsia.
作者 曾辛 王枫 黄齐香 辛思明
机构地区 江西省妇幼保健院
出处 《中国妇幼保健》 CAS 北大核心 2012年第14期2184-2186,共3页 Maternal and Child Health Care of China
关键词 MIRNA 子痫前期 胎盘 miRNA Preeclampsia Placenta
分类号 R714.244 [医药卫生—妇产科学]
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参考文献8

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同被引文献32

  • 1李东红,杨梦庚.胎盘与妊高征发病的关系[J].中华妇产科杂志,1994,29(11):687-689. 被引量：22
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  • 6Zhu XM, Han T, Sargent IL, et al. Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies[J].Am J Obstet Gynecol, 2009,200 (6) : 661.
  • 7Mayor-Lynn K, Toloubeydokhti T, Cruz AC, et al. Expression profile of mieroRNAs and mRNAs in human placentas from preg- nancies complicated by preeclampsia and preterm labor[J].Re-prod Sci,2011,18(1) :46.
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引证文献4

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中国妇幼保健
2012年 第14期

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