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一种合成原二氯乙酸三乙酯的新方法 被引量：2

A new method for the synthesis of orthodichloroacetic acid triethyl ester
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摘要 报道了以三氟三氯乙烷和乙醇钠乙醇溶液为原料,在高压釜中合成标题化合物的新方法。通过单因素实验确定了该方法的较优合成条件为:三氟三氯乙烷和乙醇钠的物质的量比为1∶5.5,反应温度为140℃,反应时间为9 h,此时目标产物的收率可达77.7%。该合成方法操作简单,反应条件较为温和。 A new method for the synthesis of orthodichloroace- tic acid triethyl ester by the reaction of 1,1,1-trichlorotriflu- oroethane and sodium alcoholate solution in autocave was re- ported. The optimistic reaction conditions confirmed by single factor method were as follows：the molar ratio of 1,1, l-tri- chlorotrifluoroethane to sodium alcoholate was 1 ： 5.5, the re- action temperature and time were 140℃ and 9 h respectively. The yield could reach to 77.7%. The characters of thissyn- thetic method is simple operation and mild reaction conditions that is suitable for industrial production.
作者 刘志政 陈志荣 尹红 袁慎峰
机构地区 浙江大学化学工程与生物工程学系
出处 《化学试剂》 CAS CSCD 北大核心 2012年第5期470-472,共3页 Chemical Reagents
关键词 原二氯乙酸三乙酯 合成 单因素实验 orthodichloroacetic acid triethyl ester synthesis single factor method
分类号 O622.5 [理学—有机化学]
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参考文献10

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同被引文献43

  • 1尹红,袁慎峰,陈志荣,等.一种连续合成三氟乙酰氯和硫酰氟的方法:CN,102351681A[P].2012-02-15.
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  • 5Hu C, Qing F, Zhang H. Reactions of perhalocarbons. Part IX. Conversion of per(poly) fluoroalkyl halides to the corresponding carboxylic acids with a redox system [ J]. J. Fluorine Chem. , 1990, 49(2) : 275 -280.
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  • 7Rudiger S, Gross U, Shekar S C, et al. Studies on the conversion of 1, 1, 1 - trichlorotrifluoroethane, chloro - 2, 2, 2 - trifluoroethane and 1, 1, 1 - trifluoroethane by catalytic oxidation, hydrolysis and ammonolysis [ J ]. Green Chemistry, 2002, 4 (6) : 541 - 545.
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化学试剂
2012年 第5期

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