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血清25-(OH)D_3与自身免疫性甲状腺疾病体液免疫的相关性 被引量:16

Correlation between serum level of 25-(OH)D_3 and humoral immunity in patients with autoimmune thyroid diseases
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摘要 目的:探讨自身免疫性甲状腺疾病(AITD)患者血清中25-(OH)D3与健康人群有无差异,及25-(OH)D3与AITD患者体液免疫紊乱之间的关系。方法:选取Graves病(GD)50例、桥本甲状腺炎(HT)30例,健康人20例,检测样本血清25-(OH)D3、甲状腺自身抗体(TSAb、TGAb、TPOAb)及甲状腺功能,并对25-(OH)D3水平与其他检测指标进行相关分析。结果:GD组及HT组25-(OH)D3均显著低于对照组,GD组25-(OH)D3与TSAb、FT3、FT4呈负相关,与TSH呈正相关;HT组25-(OH)D3与TGAb、TPOAb、TSH呈负相关,与FT3、FT4呈正相关。结论:AITD患者存在低25-(OH)D3血症,与患者的体液免疫紊乱密切相关。 Objective To investigate the difference of serum 25-(OH)D3 between patients with autoimmune thyroid diseases(AITD) and healthy subjects,and the relationship between 25-(OH)D3 level and humoral immune disorder in AITD.Methods Serum levels of 25-(OH)D3 and thyroid antibodies(TSAb,TGAb,TPOAb),and thyroid function in 50 patients with Graves diseases(GD),30 patients with hashimoto thyroiditis(HT),and 20 healthy subjects were measured,and the relationships between serum 25-(OH)D3 and the other index were analyzed.Results The serum level of 25-(OH)D3 in patients with GD or HT were obviously lower than that in healthy subjects.25-(OH)D3 in GD group was negatively associated with TSAb,FT3,and FT4,but was positively associated with TSH.While in HT group,25-(OH)D3 was negatively associated with TGAb,TPOAb,and TSH,but was positively associated with FT3 and FT4.Conclusion The patients with AITD had 25-(OH)D3 deficiency,which was related to humoral immune disorders.
出处 《实用医学杂志》 CAS 北大核心 2012年第9期1455-1457,共3页 The Journal of Practical Medicine
基金 河南省医学科技攻关项目(编号:2011020006)
关键词 自身免疫性甲状腺疾病 25-(OH)D3 甲状腺自身抗体 甲状腺功能 Autoimmune thyroid diseases 25-hydroxyvitamin D3 Thyroid antibodies Thyroid function
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