酯型儿茶素载体栓对大兔细菌性阴道炎作用

Treatment effect of carrier suppository with ester-catechins on bacterial vaginitis in rabbits

目的研究酯型儿茶素载体栓对细菌性阴道炎的治疗作用。方法新西兰大白兔分为5组,即模型对照、妇康载体栓及酯型儿茶素低、中、高剂量(29、58、116 mg/kg)组。采用金黄色葡萄球菌和大肠埃希菌的混合菌液直接注入新西兰大白兔阴道内复制成细菌性阴道炎模型,观察酯型儿茶素载体栓对细菌性阴道炎的作用。结果连续7 d阴道局部给药,治疗大白兔细菌性阴道炎,酯型儿茶素载体栓中、高剂量组的疗效与妇康载体栓组相同,治愈率可达83.3%,有效率为100%;细菌学检测,与模型组比较,酯型儿茶素载体栓中、高剂量组和妇康载体栓组均可明显抑制金黄色葡萄球菌和大肠埃希菌的生长(P<0.05)。结论酯型儿茶素载体栓对新西兰大白兔的细菌性阴道炎有明显治疗作用。

Objective To evaluate the therapeutic effect of vaginal carrier suppository with ester-catechins on bacterial vaginitis. Methods New Zealand big white rabbits（36） were randomly assigned to 6 groups：normal control group,model control group,Fukang carrier suppository group,and three groups of vaginal carrier suppository with ester-catechins.The bacterial vaginitis model was established by injecting the mixture bacteria of Staphylococcus aureus and Escherichia coli into the vagina of the rabbits and the effect of vaginal carrier suppository with ester-catechins on the bacterial vaginitis was observed. Results After local application of vaginal carrier suppository with ester-catechins for 7 consecutive days,the moderate and high dose treatments showed the same effectiveness as Fukang carrier suppository with a curative rate of 83.3%.Compared to the model control group,both the moderate and high dose of the vaginal carrier suppository with ester-catechins markedly inhibited the growth of Staphylococcus aureus and Escherichia coli. Conclusion The vaginal carrier suppository with ester-catechins showed remarkable therapeutic effect for bacterial vaginitis in rabbits.