中毒所致的发作性睡病

Narcolepsy caused by poisoning

目的加强对中毒所致的发作性睡病的认识。方法对2例中毒后出现发作性睡病患者的临床资料进行分析,并对一些相关文献进行复习。结果发作性睡病包括原发性及继发性,中毒所致的发作性睡病属继发性。白天发作性嗜睡、猝倒、睡眠瘫痪以及睡眠幻觉是该病的4个主要症状。发作性睡病与病理性REM睡眠相关。结论中毒也可能导致发作性睡病,但可能不被识别而被误诊为其他疾病,有必要加强对发作性睡病以及REM睡眠的认识。

【Objective】 To strengthen the realization about narcolepsy caused by poisoning.【Methods】 We analyzed the clinical data of two patients emerging narcolepsy after poisoning,and reviewed some relevant literatures.【Results】 Narcolepsy include primary and secondary narcolepsy,and narcolepsy caused by poisoning is secondary.Paroxysmal daytime sleepiness,cataplexy,sleep paralysis,and hypnagogic hallucinations were the four major symptoms of this disease.Narcolepsy was related with pathological REM sleep.【Conclusions】 Poisoning may induce narcolepsy,but it cannot be diagnosed easily or misdiagnosed.It is essential to strengthen the realization about narcolepsy and REM sleep.