摘要
目的比较度洛西汀与文拉法辛治疗恶劣心境的临床疗效及不良反应。方法对66例恶劣心境的住院患者,随机分为两组,度洛西汀组和文拉法辛组各33例。治疗6周,采用汉密尔顿抑郁量表(HAM D),汉密尔顿焦虑量表(HAMA)和临床疗效总评量表病情严重程度(CG I-S I)评定疗效,用抗抑郁药副反应评定量表(SERS)评定药物副反应。结果经6周治疗,度洛西汀组和文拉法辛组有效率分别为87.88%和84.85%,两组疗效差异无统计学意义(P>0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论度洛西汀和文拉法辛对产后抑郁的疗效相当,不良反应较少,值得临床推广。
Objective To investigate the clinical efficacy and side effect of dutoxetine and venlafaxine in the treatment of dysthymia.Method A total of 66 cases were divided into two groups randomly,treated with dutoxetine and venlafaxine respectively for 6 weeks.The Hamilton depressions scale（HAMD）and Hamilton anxiety scale（HAMA）,clinical global impression scale（CGI-SI）and rating scale for side effects（SERS）were used to assess the therapeutic effect and side effect respectively.Results The effective rate of dutoxetine group and venlafaxine group were 87.88% and 84.85% respectively.There was not significant difference between two group in improvement rate and side effect（P0.05）.Conclusion Dutoxetine is as effective as venlafaxine in the treatment of dysthymia with fewer side effect.
出处
《中国健康心理学杂志》
2012年第4期515-516,共2页
China Journal of Health Psychology
