基质金属蛋白酶与基质金属蛋白酶抑制剂在光老化中作用的研究进展

Roles of matrix metalloproteinase and tissue inhibitors of metalloproteinases in photoaging

紫外线照射会给人体的皮肤造成有害影响，其中，光老化是目前公认的长期暴露于紫外线照射所造成的主要危害之一。紫外线照射导致了基质金属蛋白酶家族的表达增加，其可降解真皮中的胶原及其他细胞外基质蛋白。大量的皮肤正常结缔组织结构的破坏损害了皮肤的功能并引起皮肤的老化。基质金属蛋白酶抑制剂是基质金属蛋白酶家族特异性的内源性抑制剂，并参与调控其在机体组织中的活性变化。二者之间的平衡在皮肤光老化的发生与发展中占有举足轻重的地位。

Ultraviolet （UV） irradiation has harmful effects on human skin. Photoaging is currently considered as a primary harmful effect of chronic solar UV exposure. UV irradiation can induce increased expression of certain members of the matrix metalloproteinase （MMP） family, which in turn degrade dermal collagen and other extracellular matrix （ECM） proteins, then lead to the disruption of normal architecture of skin connective tissue followed by the impairment of skin function and aging of skin. Tissue inhibitors of metalloproteinases （TIMPs） are considered as the specific endogenous inhibitor of matrix metalloproteinases （MMPs）, and participate in the regulation of MMP activity. The balance between MMPs and TIMPs plays an important role in the occurrence and development of skin aging.