细胞因子在深部真菌感染中的实验研究进展

Cytokines in deep fungal infection： advances in experimental study

细胞因子在深部真菌感染发展过程中，起着重要的免疫调节作用。近年来，免疫调节治疗也逐渐成为深部真菌感染治疗的热点。细胞因子主要包括促炎和抗炎细胞因子两大类，前者主要有肿瘤坏死因子-α、集落刺激因子、干扰素-γ、白介素-12等；后者主要包括白介素-4、白介素-10等。促炎细胞因子在免疫应答和免疫调节过程中的重大作用使其在治疗深部真菌感染中具有很大的应用潜力。为此，文中概述细胞因子在深部真菌感染中的作用。

Cytokines play an important immunomodulatory effect in the development of deep fungal infection. Recently, immunomodulation therapy has gradually become a hot spot in the treatment of deep fungal infection. Cell factors are mainly classified into 2 categories： pro-inflammatory cytokines and anti-inflammatory cytokines. Pro-inflammatory cytokines mainly include tumor necrosis factor （TNF）-α, colony stimulating factor （CSF）, interferon-γ （IFN-γ）, interleukin-12 （IL-12）, etc, and anti-inflammatory cytokines include IL-4, IL-10, and so on. The essential roles of pro-inflammatory cytokines in immune response and immune regulation make them have great potential for the treatment of deep fungal infection. This paper focuses on the roles of cytokines in deep fungal infection.