力学刺激促进成骨和骨再生

Mechanical stimulation enhances osteogenesis and bone generation

肌骨系统的结构与功能、疾病的防治与康复均与力学环境和干预存在着密切的关系。伴随细胞分子生物学的发展,骨科生物力学研究从器官、组织水平深入到细胞、分子、基因水平。医用生物力学的发展促进了基于力学刺激原理的理疗设备的研发,使力学刺激促进成骨和骨再生成为目前骨科基础和应用研究的热点。《医用生物力学》杂志近年来刊登了一系列力学刺激对肉骨系统的基础和应用研究,这次选登了几项力学刺激促进成骨和骨再生,尤其在具有挑战性的骨折疏松骨折愈合促进方面的基础和应用基础成果,借此进一步加强相关领域中紧密结合临床需求的科学研究的开展。

Mechanical environment and intervention do have effects on both structure and function of musculoskeletal system,prevention and treatment of related disorders as well as its rehabilitation.With rapid advancement in cellular and molecular biology,biomechanics in musculoskeletal research has extended from organ and tissue level to cellular,molecular and gene level.The development of medical biomechanics promotes research and development of mechanical stimulation-based medical devices and accordingly,how mechanical stimulation can enhance osteogenesis and bone regeneration has become a hot basic and applied research area in orthopaedics.The Journal of Medical Biomechanics has published a series of basic and applied research work on potentials of biomedical stimulations for musculoskeletal systems.In this issue,the Journal specifically selected a few original efficacy and mechanistic research on mechanical stimulation for enhancing osteogenesis and bone regeneration in challenging osteoporotic fracture repair.Such efforts would help to facilitate more clinical orientated scientific research.