摘要
目的了解医院2007-2009年临床分离的革兰阴性杆菌分布及对抗菌药物的耐药性,为临床治疗提供帮助。方法细菌鉴定采用VITEK微生物分析仪,药物敏感试验采用K-B纸片琼脂扩散法,对细菌药敏试验结果进行统计分析。结果 2007年1月-2009年12月分离出常见革兰阴性杆菌2505株,其中大肠埃希菌1280株,铜绿假单胞菌485株,肺炎克雷伯菌385株,鲍氏不动杆菌202株,检出率依次为51.5%、19.4%、15.4%、8.0%,其他革兰阴性杆菌153株;大肠埃希菌和肺炎克雷伯菌对阿米卡星、阿莫西林/克拉维酸、头孢哌酮/舒巴坦的耐药率均<40.0%,对亚胺培南的耐药率<1.0%,对阿莫西林、磺胺甲噁唑/甲氧苄啶耐药率较高,为65.3%~100.0%;铜绿假单胞菌对头孢哌酮/舒巴坦、亚胺培南、头孢吡肟的耐药率较低,均<40.0%,对替卡西林和磺胺甲噁唑/甲氧苄啶耐药率较高,为74.6%~93.5%,鲍氏不动杆菌对头孢哌酮/舒巴坦的耐药率较低,<17.0%;大肠埃希菌和肺炎克雷伯菌的产ESBLs检出率为52.3%和32.9%。结论加强临床病原菌及其耐药性监测,有助于临床合理使用抗菌药物和提高治疗效果。
OBJECTIVE To understand the distribution and drug resistance of the clinical isolates of gram-negative bacilli from 2007 to 2009,so as to provide basis for clinical treatment.METHODS The bacteria were identified by VITEK microbial analyzer,the K-B agar diffusion was used to perform the drug susceptibility testing,then the result of the drug susceptibility testing was statistically analyzed.RESULTS There were 2505 strains of common gram-negative bacilli isolated from Jan 2007 to Dec 2009,including 1280 strains of E.coli,485 strains of P.aeruginosa,385 strains of K.pneumoniae,and 202 strains of A.baumannii,the detection rates were 51.5%,19.4%,15.4%,and 8.0%,respectively,there were 153 strains of other gram-negative bacilli detected as well;E.coli and K.pneumoniae had the low drug resistance to amikacin,amoxicillin/clavulanate,cefoperazone/sulbactam,and imipenem,but had the high drug resistance to amoxicillin and sulfamethoxazole/trimethoprim;P.aeruginosa had the low drug resistance to cefoperazone/sulbactam,imipenem,and cefepime,but had the high resistance to ticarcillin and sulfamethoxazole/trimethoprim;A.baumannii had the low resistance to cefoperazone/sulbactam;the detection rates of ESBLs-producing E.coli and K.pneumoniae were 52.3% and 32.9%,respectively.CONCLUSION To strengthen the surveillance of antimicrobial resistance of pathogens can help the clinical doctors to use antimicrobial agents reasonably and improve the effect of treatment.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第9期1909-1911,共3页
Chinese Journal of Nosocomiology
关键词
革兰阴性杆菌
抗菌药物
耐药性
Gram-negative bacilli
Antibiotics
Drug resistance