产ESBLs肺炎克雷伯菌的目标性监测与分析

Targeted monitoring and analysis of ESBLs-positive Klebsiella pneumoniae

目的了解临床产ESBLs肺炎克雷伯菌的分离和耐药性,探索产ESBLs肺炎克雷伯菌感染病例的监控措施。方法对2010年临床分离的致病菌进行目标性监测,统计出产ESBLs肺炎克雷伯菌的株数及耐药率,并对临床产ESBLs肺炎克雷伯菌感染病例实施监控。结果全年检测结果发现,共分离出肺炎克雷伯菌1215株,其中产ESBLs肺炎克雷伯菌占22.3%;对抗菌药物耐药率较高;全院未发生产ESBLs肺炎克雷伯菌的暴发和流行。结论产ESBLs肺炎克雷伯菌分离株数较多,耐药率较高,应加强临床合理使用抗菌药物的管理,对产ESBLs肺炎克雷伯菌感染病例实施监控,预防和减少多药耐药菌的产生,控制医院感染。

OBJECTIVE To understand the isolation and drug resistance of ESBLs-positive K.pneumoniae and explore control measures of ESBLs-positive K.pneumoniae infections.METHODS Targeted monitoring of clinical isolates of pathogens was performed in 2010,ESBLs-positive K.pneumoniae and the drug resistance were statistically analyzed,the surveillance for ESBLs-positive K.pneumoniae infections was performed.RESULTS According to the findings in the whole year,a total of 1215 strains of K.pneumoniae were isolated,among which ESBLs-positive isolates accounted for 22.30%;the resistance rate was high;there was no outbreak and prevalence of ESBLs-positive K.pneumoniae.CONCLUSION There are so many strains of ESBLs-positive K.pneumoniae isolated with high drug resistance,it is necessary to intensify the management of reasonable use of antibiotics,monitor the ESBLs-positive K.pneumoniae infections so as to prevent and reduce the resistant strains and control the nosocomial infections.