MRSA医院感染及耐药性研究

Study on MRSA infection and drug resistance

目的了解耐甲氧西林金黄色葡萄球菌(MRSA)医院感染及耐药性的情况。方法采用回顾性调查方法,对医院在2008年1月-2010年12月住院期间确诊为MRSA医院感染的患者进行分析。结果 MRSA医院感染133例,149例次,其中下呼吸道感染105例,占70.5%,菌血症8例,占5.4%,表浅切口7例,占4.7%;多集中在神经外科、综合ICU和干部病房;未发现对万古霉素、替考拉宁、利奈唑胺耐药株。结论 MRSA是医院感染的重要致病菌,了解其临床分布,加强耐药监测,规范临床用药,可有效预防耐药菌的产生。

OBJECTIVE To evaluate the methicillin-resistant Staphylococcus aureus（MRSA） causing nosocomial infections and drug resistance.METHODS By the means of the retrospective survey,the hospitalized patients who were diagnosed as MRSA infections from Jan 2008 to Dec 20010 were analyzed.RESULTS There were totally 133 cases with MRSA infection（149 case-times）,among which there were 105（70.5%）cases with lower respiratory tract infection,8（5.4%） cases with bacteremia,and 7（4.7%） cases with incisions;most of the cases distributed in neurosurgery department,ICU and geriatric department;no strains resistant to vancomycin,Ticoplanin,and linezolid were detected.CONCLUSION MRSA isolates are the main pathogens causing nosocomial infections,it is necessary to probe into its clinical distribution,strengthen the drug resistance surveillance,and standardize the clinical medication so as to restrain the resistant strains.