瑞舒伐他汀对高血压患者的降压作用

Effects of Rosuvastatin Lowering Blood Pressure in Hypertensive Patients

目的探讨瑞舒伐他汀是否对伴高脂血症的高血压患者有降压作用。方法 52例高血压合并高脂血症患者,分为两组:治疗组使用瑞舒伐他汀10 mg/d+坎地沙坦8 mg/d,对照组仅使用坎地沙坦8 mg/d,观察6个月,进行血压控制的疗效比较。结果治疗组收缩压平均下降10.2 mmHg,对照组平均下降7.5 mmHg(P<0.05);治疗组脉压差平均下降6 mmHg,对照组平均下降3 mmHg(P<0.05);治疗组舒张压平均下降4.9 mmHg,对照组平均下降4.2 mmHg(P>0.05)。结论瑞舒伐他汀与坎地沙坦合用比单用坎地沙坦对高血压合并高脂血症患者的收缩压和脉压有较好的降压作用,但对舒张压无显著影响。

Aim To determine whether rosuvastatin lowers blood pressure （BP） in hypertension with hyperlipi- demia patients. Methods 52 cases of hypertension with hyperlipidemia patients were divided into treatment group （ using rosuvastation 10 mg/L ＋ candesartan 8 mg/d） and control group （ only using candesartan 8 mg/d）. Observed for six months, the efficacy of blood pressure control was compared. Results Systolic blood pressure （SBP） fell by an average of 10. 2 mmHg in the treatment group, SBP fell by an average of 7. 5 mmHg in the control group （ P 〈 0. 05 ）. Pulse pressure （PP） fell by an average of 6 mmHg in the treatment group, PP fell by an average of 3 mmHg in the control group （ P 〈 0. 05 ）. Diastolic blood pressure （DBP） fell by an average of 4. 9 mmHg in the treatment group, DBP fell by an average of 4. 2 mmHg in the control group （ P 〉 0. 05 ）. Condlmions Rosuvastation ＋ candesartan had a signifi- cant effect on lowering SBP and PP in hypertension with hyperlipidemia patients campared with only using candesartan, but had no effect on DBP.