吡格列酮对2型糖尿病患者血清视黄醇结合蛋白4和网膜素1的影响

The Effect of Pioglitazone on Serum RBP 4 and Omentin 1 in Type 2 Diabetes Patients

目的观察吡格列酮对2型糖尿病患者血清视黄醇结合蛋白4(RBP4)和网膜素1的影响。方法选择80例新诊断2型糖尿病患者,随机分为对照组和吡格列酮组,每组40例,治疗3个月。比较两组患者治疗前后空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)及血清RBP4和网膜素1的水平变化。结果与对照组比较,吡格列酮组治疗后FPG和HOMA-IR明显降低(P<0.05),血清RBP4水平也明显降低(P<0.01),而网膜素1水平明显升高(P<0.01)。Pearson相关分析显示,RBP4与FPG、体质指数及HOMA-IR呈正相关,与低密度脂蛋白呈负相关(P<0.05);网膜素1与低密度脂蛋白呈正相关,与FPG、体质指数及HOMA-IR呈负相关(P<0.05)。结论吡格列酮可能通过调节血清RBP4和网膜素1水平而改善胰岛素抵抗。

Aim To observe the effect of pioglitazone on serum retinol binding protein 4 （RBP4） and omentin 1 in type 2 diabetes mellitus patients. Methods 80 cases with type 2 diabetes mellitus were randomly divided into two groups： placebo group and pioglitazone group, 40 cases in each group, for a period of 3 months. Levels of fasting blood glucose, insulin resistance index （HOMA-IR）, serum RBP4 and omentin 1 before and after treatment were compared in the two groups. Results Compared with placebo group, fasting blood glucose and HOMA-IR in pioglitazone group were obviously decreased after treatment （P 〈0. 05）, the level of serum RBP4 was decreased （P 〈0. 01 ）, but omentin 1 was increased （P 〈 0. 01 ）. Pearson correlation analysis showed that RBP4 was positively correlated with FPG, BMI and HOMA-IR, but negatively correlated with LDL （P 〈 0. 05）. Omentin 1 was positively correlated with LDL, but negative- ly correlated with FPG, BMI and HOMA-IR （P 〈 0. 05）. Conclusion Pioglitazone can improve insulin resistance through the regulation of serum RBP4 and omentin 1 level.