瑶山润楠根的化学成分研究

Chemical constituents from roots of Machilus yaoshansis

对樟科润楠属植物瑶山润楠Machilus yaoshansis根乙醇提取物的化学成分进行研究。利用多种色谱技术从瑶山润楠的醋酸乙酯萃取物中分离得到15个化合物;通过理化性质和波谱数据鉴定其结构为12个木脂素类(+)-愈创木素(1),kadsuralignan C(2),(+)-异落叶松脂素(3),(+)-5'-甲氧基异落叶松脂素(4),南烛木树脂酚(5),内消旋-裂环异落叶松树脂酚(6),异落叶松脂素-9'-O-β-D-吡喃木糖苷(7),5'-甲氧基-异落叶松脂素-9'-O-β-D-吡喃木糖苷(8),南烛木树脂酚9'-O-β-D-吡喃木糖苷(9),(2R,3R)-2,3-二氢-2-(4-羟基-3-甲氧基苯基)-7-甲氧基-3-甲基-5-(E)-丙烯基苯并呋喃(10),3,5'-二甲氧基-4',7-环氧-8,3'-新木脂素-4,9,9'-三醇(11),甘密树皮素B(12),和3个黄烷类(+)-儿茶素(13),(-)-表儿茶素(14),bis-8,8'-catechinylmethane(15)。化合物1～15均为首次从该植物中分离得到。

To study chemical constituents contained in ethanol extracts from roots of Machilus yaoshansis.Fifteen compounds were separated from the roots of M.yaoshansis by using various chromatographic techniques.Their structures were identified on the basis of their physicochemical properties and spectral data as twelve lignans（＋）-guaiacin（1）,kadsuralignan C（2）,（＋）-isolariciresinol（3）,5′-methoxy-（＋）-isolariciresinol（4）,（7′S,8R,8′R）-lyoniresinol（5）,meso-secoisolariciresinol（6）,isolariciresinol-9′-O-β-D-xylopyranoside（7）,5′-methoxy-isolariciresinol-9′-O-β-D-xylopyranoside（8）,lyoniresinol-9′-O-β-D-xylopyranoside（9）,（2R,3R）-2,3-dihydro-2-（4-hydroxy-3-methoxyphenyl）-7-methoxy-3-methyl-5-（E）-propenylbenzofuran（10）,3,5′-dimethoxy-4′,7-epoxy-8,3′-neolignan-4,9,9′-triol（11）,nectandrin B（12）,and three flavanes（＋）-catechin（13）,（-）-epicatechin（14）,and bis-8,8′-catechinylmethane（15）.All of the compounds 1-15 were separated from M.yaoshansis for the first time.