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Caveolin-1在食管鳞癌中的表达及其临床意义 被引量：7

Expression and clinical significance of Caveolin-1 in esophageal squamous cell carcinoma
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摘要 目的探讨Caveolin-1蛋白在食管鳞癌中的表达及其临床意义。方法应用免疫组化法和免疫印迹法检测65例食管鳞癌患者的癌组织及对应癌旁正常食管黏膜中Cave-olin-1的表达情况。结果食管鳞癌组织中Caveolin-1蛋白的表达水平高于对应癌旁正常食管黏膜,差异有统计学意义(P<0.05),食管鳞癌组织中Caveolin-1蛋白的表达水平与其分化程度相关(P<0.05),与淋巴结转移、TNM分期等无关。结论 Caveolin-1蛋白在食管鳞癌中的高表达可能与其发生发展有关。 Objective To investigate the expression and clinic characteristics of Caveolin-1 in esophageal squamous cell carcinoma（ESCC）.Methods Expression of Caveolin-1 in 65 patients of ESCC and normal esophageal epithelial tissue were detected by immunohistochemistry and Western blot analysis.Results The expression level of Caveolin-1 was significantly higher in ESCC than that in the normal esophageal epithelial tissue（P〈0.01）,and up-regulation of Caveolin-1 was correlated with differentiation of ESCC.It had no relationship with lymph node metastasis or TNM stage.Conclusion The overexpression of Caveolin-1 may play an important role in the progression of human ESCC.
作者 葛腾飞 朱克超 于在诚 汪渊
机构地区 安徽医科大学第一附属医院胸外科 安徽医科大学分子生物学实验室
出处 《安徽医科大学学报》 CAS 北大核心 2012年第5期544-547,共4页 Acta Universitatis Medicinalis Anhui
基金 国家自然科学基金(编号:30471427) 安徽省科技厅重点科研项目(编号:07021017)
关键词 食管肿瘤 鳞状细胞 免疫组织化学 免疫印迹法 CAVEOLIN-1 esophageal neoplasms squamous cell immunohistochemistry Western blot Caveolin-1
分类号 R735.1 [医药卫生—肿瘤] R341 [医药卫生—基础医学]
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参考文献16

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共引文献2

同被引文献75

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安徽医科大学学报
2012年 第5期

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